GSK 2636771 dihydrochloride
GSK2636771
CAS: 1372540-25-4
Molecular Formula: C22H22F3N3O3
GSK 2636771 dihydrochloride - Names and Identifiers
GSK 2636771 dihydrochloride - Physico-chemical Properties
| Molecular Formula | C22H22F3N3O3 |
| Molar Mass | 433.42 |
| Density | 1.38 |
| Melting Point | >225°C (dec.) |
| Boling Point | 641.3±55.0 °C(Predicted) |
| Solubility | DMSO 28 mg/mL Water <1 mg/mL Ethanol <1 mg/mL |
| Appearance | Solid |
| Color | Pale Yellow |
| pKa | -2.70±0.30(Predicted) |
| Storage Condition | -20°C Freezer |
| In vitro study | GSK-2636771 has selective inhibitory activity against PTEN-deficient cell lines (human prostate cancer PC-3 and breast cancer HCC70) with EC50 of 36 nM and 72 nM, respectively. |
| In vivo study | These xenograft models were treated GSK-2636771 to reduce the level of the phosphorylated protein kinase Akt(Ser473). Treatment of mice with GSK-2636771(100 mg/kg) did not increase glucose/insulin levels. |
GSK 2636771 dihydrochloride - Introduction
GSK2636771 is an orally biopotent PI3Kβ selective inhibitor sensitive to PTEN deletion cell lines.
Last Update：2022-10-16 17:41:27
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View History
GSK 2636771 dihydrochloride
PECTIC ACID FROM APPLES
PENTAETHYLENE GLYCOL MONOMETHYL ETHER
2,5-difluoro-4-aminobenzoic acid
1F-β-D-Fructosylraffinose
[2H3]-(Α-Β9-THC-COOH
2-NAPHTHYL 2-[(PHENYLSULFONYL)-3-(TRIFLUOROMETHYL)ANILINO]ACETATE
5-O-TERT-BUTYL 1-O-ETHYL 3-AMINO-6,6-DIMETHYL-4H-PYRROLO[3,4-C]PYRAZOLE-1,5-DICARBOXYLATE
Isopropyl Cyclohexanecarboxylate
ANTI-CALPAIN-7 (DOMAIN I, N-TERMINAL), LARGE SUBUNIT
PECTIC ACID FROM APPLES
PENTAETHYLENE GLYCOL MONOMETHYL ETHER
2,5-difluoro-4-aminobenzoic acid
1F-β-D-Fructosylraffinose
[2H3]-(Α-Β9-THC-COOH
2-NAPHTHYL 2-[(PHENYLSULFONYL)-3-(TRIFLUOROMETHYL)ANILINO]ACETATE
5-O-TERT-BUTYL 1-O-ETHYL 3-AMINO-6,6-DIMETHYL-4H-PYRROLO[3,4-C]PYRAZOLE-1,5-DICARBOXYLATE
Isopropyl Cyclohexanecarboxylate
ANTI-CALPAIN-7 (DOMAIN I, N-TERMINAL), LARGE SUBUNIT